Introduction to Bioorganic Chemistry and Chemical Biology is the first textbook to blend modern tools of organic chemistry with concepts of biology, physiology, and medicine. With a focus on human cell biology and a problems-driven approach, the text explains the combinatorial architecture of biooligomers (genes, DNA, RNA, proteins, glycans, lipids, and terpenes) as the molecular engine for life. Accentuated by rich illustrations andmechanistic arrow pushing, organic chemistry is used to illuminate the central dogma of molecular biology.
Introduction to Bioorganic Chemistry and Chemical Biology is appropriate for advanced undergraduate and graduate students in chemistry and molecular biology, as well as those going into medicine and pharmaceutical science.
Bioorganic chemistry is a scientific discipline that combines organic chemistry and biochemistry. It is that branch of life science that deals with the study of biological processes using chemical methods. Protein and enzyme function are examples of these processes.
Sometimes biochemistry is used interchangeably for bioorganic chemistry; the distinction being that bioorganic chemistry is organic chemistry that is focused on the biological aspects. While biochemistry aims at understanding biological processes using chemistry, bioorganic chemistry attempts to expand organic-chemical researches (that is, structures, synthesis, and kinetics) toward biology. When investigating metalloenzymes and cofactors, bioorganic chemistry overlaps bioinorganic chemistry.
The following is an excellent review on peptide ligation and combinatorial chemistry and is highly recommended. You can download a pdf version free of charge from a computer with a Vanderbilt IP address.
Grading: Each exam with count equally toward the final grade. Graduate students are also required to write a short paper (10 page limit) on a topic of their choice (with approval from me), related to bioorganic chemistry. In addition, they will present a short lecture (15 minutes) on their topic. You should choose a topic by Oct. 30.
Tutorial Reviews are concise, accessible and authoritative overviews of important contemporary topics in the chemical sciences. They should appeal to advanced undergraduates, the general research chemist who is new to the field, as well as the expert. They provide a solid introduction to the development of a subject, the latest breakthrough results and their implications for the wider scientific community. Tutorial Reviews should not contain unpublished research.
This degree offers students the opportunity to develop in-depth knowledge in five areas of biological chemistry (bioorganic, bioinorganic, bioanalytical, biophysical, and health sciences). The program teaches key chemical concepts and develops student ability to apply them to a wide variety of biological problems. The program serves to develop and train graduates who will be well prepared to enter graduate or professional schools as well as careers in the chemical, pharmaceutical, biomedical, agricultural and bioinformatic industries.
Admission requirements for this program are satisfied by the general requirements for undergraduate admission to the University. Students planning to major in biochemistry and chemical biology should consult with an advisor in the Chemistry Department not later than the beginning of their sophomore year.
Chemical biology presents a framework for the modern approach to studying the complexities of biological processes. It is already a leading focal point for research in the 21st century, integrating concepts and information from the molecular to the cellular level. This interdisciplinary degree program has participants from the departments of Chemistry, Biology, Biochemistry and Molecular Biology, Medicinal Chemistry and Pharmacology within the College of Humanities and Sciences and the schools of Medicine and Pharmacy.
The Department of Chemistry offers programs leading to the Bachelor of Science, Master of Science and Doctor of Philosophy degrees. For undergraduate students, the Bachelor of Science offers concentrations in chemical science, professional chemist, professional chemist with honors, biochemistry and chemical modeling.
Chemistry is concerned with the preparation, composition, and structure of matter and with the equilibrium and kinetic laws that govern its transformations. The BA and BS degrees in Chemistry are designed to provide a broad foundation in the three principal branches of the science: inorganic, organic, and physical chemistry. Analytical chemistry, often regarded as an independent branch, is incorporated into the program. Both curricula discuss experimental and theoretical work and emphasize their interdependence. Both degree programs prepare the student for a career in chemistry. However, the BS degree offers a more intensive program of study. The BA degree also offers thorough study in the field of chemistry, but it provides a wide opportunity for elective freedom and for the pursuit of interdisciplinary interests in areas such as biochemistry, biophysics, chemical physics, geochemistry, pre-medicine, and education, as well as the ability to double major with many other departments in a straightforward way.
Enrollment by placement only. The first two courses in this sequence meet the general education requirement in the physical sciences. This three-quarter sequence is a comprehensive survey of modern descriptive, inorganic, and physical chemistry for students with a good secondary school exposure to general chemistry. We cover atomic and molecular theories, chemical periodicity, chemical reactivity and bonding, chemical equilibria, acid-base equilibria, solubility equilibria, phase equilibria, thermodynamics, electrochemistry, kinetics, quantum mechanics, and nuclear chemistry. Examples are drawn from chemical, biological, and materials systems. The laboratory portion includes an introduction to quantitative measurements, investigation of the properties of the important elements and their compounds, and experiments associated with the common ions and their separation and identification. Attendance at one discussion session per week and laboratory sessions is required.
An introduction to chemistry for chemistry majors. Includes gases, atomic theory, bonding, and thermodynamics. For 301C, three lecture hours a week for one semester; for 401C three lecture and three laboratory hours a week for one semester. Only one of the following may be counted: Chemistry 301, 301C, 301H, 301N, 304K.
Designed for non-science and Textiles and Apparel majors. Examine the nature of matter, energy, chemical reactions, and chemical thermodynamics. Discuss how these fundamentals of chemistry relate to real-world applications. Not intended as preparation for Chemistry 301. Three lecture hours a week for one semester. Only one of the following may be counted: Chemistry 301, 301C, 301H, 301N, 304K.
An introduction to chemistry for chemistry majors. Includes equilibria, kinetics, nuclear chemistry, inorganic chemistry, and electrochemistry. For 301C, three lecture hours a week for one semester; for 401C three lecture hours and three laboratory hours a week for one semester. Only one of the following may be counted: Chemistry 302, 302C, 302H, 302N, 305. Prerequisite: Chemistry 301C with a grade of C- or higher.
Primarily for chemistry and chemical engineering majors. The development of organic chemical structure, nomenclature, and reactivity. Three lecture hours a week for one semester. Only one of the following may be counted: Chemistry 320M, 328C, 328M. Prerequisite: Chemistry 302, 302C, 402C, or 302H with a grade of at least C-.
Primarily for chemistry and chemical engineering majors. The development of organic chemical reactivity, with an emphasis on synthesis and polymers. Three lecture hours a week for one semester. Only one of the following may be counted: Chemistry 320N, 328N, 329C. Prerequisite: The following coursework with a grade of at least C- in each: Chemistry 328M and 128K.
Issues and techniques in secondary school teaching of chemical sciences. Three lecture hours a week for two semesters. For students seeking the Bachelor of Science in Chemistry: Teaching Option degree. May not be counted toward any other degree in chemistry or biochemistry. Prerequisite: For 644A, eight semester hours of coursework in organic chemistry and credit or registration for Chemistry 144K; for 644B, Chemistry 644A, 144K, and credit or registration for Chemistry 144L.
Development of classroom demonstrations, laboratory experiments, and teaching aids for secondary school teaching of the chemical sciences. Two laboratory hours a week for one semester. For students seeking the Bachelor of Science in Chemistry: Teaching Option degree. May not be counted toward any other degree in chemistry. Prerequisite: Credit or registration for Chemistry 644A.
Development of classroom demonstrations, laboratory experiments, and teaching aids for secondary school teaching of the chemical sciences. Two laboratory hours a week for one semester. For students seeking the Bachelor of Science in Chemistry: Teaching Option degree. May not be counted toward any other degree in chemistry. Prerequisite: Credit or registration for Chemistry 644B.
An introduction to the analysis and interpretation of data gathered from chemical instrumentation. Three lecture hours a week for one semester. Prerequisite: Mathematics 408D or 408M. Credit with a grade of at least C- in Physics 316 and 116L, or Physics 303L and 103N.
For chemistry and chemical engineering majors. Equations of state, laws of thermodynamics, ideal and nonideal solutions, phase equilibria, thermodynamics of chemical reactions. Three lecture hours a week for one semester. Chemistry 353 and 353M may not both be counted. Prerequisite: Mathematics 408C and 408D, or two of the following: Mathematics 408K, 408L, 408M, 408N, 408S; Chemistry 302, 302C, 402C, or 3